Schools & departments

A selection of six molecules

The Lusby Group

Publications

Photoswitchable Catalysis by a Self-Assembled Molecular Cage

Ray G DiNardi, Samina Rasheed, Simona S Capomolla, Man Him Chak, Isis A Middleton, Lauren K Macreadie, Jake P Violi, William A Donald, Paul J Lusby*, Jonathon E Beves*

Photoswitchable Catalysis by a Self-Assembled Molecular Cage

 J. Am. Chem. Soc. 2024, 146, 21196−21202 

DOI: https://pubs.acs.org/doi/10.1021/jacs.4c04846
Origins of High-Activity Cage-Catalyzed Michael Addition

Patrick J Boaler, Tomasz K Piskorz, Laura E Bickerton, Jianzhu Wang, Fernanda Duarte*, Guy C Lloyd-Jones*, Paul J Lusby*

Origins of High-Activity Cage-Catalyzed Michael Addition

DOI: https://pubs.acs.org/doi/10.1021/jacs.4c05160
Comparing organic and metallo-organic hydrazone molecular cages as potential carriers for doxorubicin delivery

Giovanni Montà-González, David Bastante-Rodríguez, Alba García-Fernández, Paul J. Lusby*, Ramón Martínez-Máñez* and  Vicente Martí-Centelles*

Comparing organic and metallo-organic hydrazone molecular cages as potential carriers for doxorubicin delivery

Chem. Sci., 2024, 15, 10010-10017

DOI: 10.1039/D4SC02294G
Exo-cage catalysis and initiation derived from photo-activating host–guest encapsulation

 

Rebecca L. Spicer, Helen M. O'Connor, Yael Ben-Tal, Hang Zhou, Patrick J. Boaler, Fraser C. Milne, Euan K. Brechin*, Guy. C. Lloyd-Jones* and Paul J. Lusby*

Exo-cage catalysis and initiation derived from photo-activating host–guest encapsulation.

Chem. Sci., 2023,14, 14140-14145

DOI: https://doi.org/10.1039/D3SC04877B
Picking the Lock of Coordination Cage Catalysis

Piskorz, T. K.; Martí-Centelles, V.; Spicer, B.; Lusby, P. J.; Duarte, F

Picking the Lock of Coordination Cage Catalysis

Chem. Sci., 2023, 14, 11300-11331

DOI: https://doi.org/10.1039/D3SC02586A
toc

Vasdev, R. A. S.; Preston, D.; Casey-Stevens, C. A.; Martí-Centelles, V.; Lusby, P. J.; Garden, A.. L.; Crowley, J. D.

Exploiting Supramolecular Interactions to Control Isomer Distributions in Reduced-Symmetry [Pd2L4]4+ Cages.

Inorg. Chem., 2022,

DOI: 10.1021/acs.inorgchem.2c00937
cages

Singh, M. K.; Etcheverry-Berríos, A.; Vallejo, J.; Sanz, S.; Martínez-Lillo, J.; Nichol, G. S.; Lusby, P. J.; Brechin, E. K.

Guest-induced magnetic exchange in paramagnetic [M2L4]4+ coordination cages.

Dalton Trans., 2022, 51, 8377-8381

DOI: 10.1039/D2DTO1385A
toc

O'Connor, H. M.; Tipping, W. J.; Vallejo, J.; Nichol, G. S.; Faulds, K.; Graham, D.; Brechin, E. K.; Lusby, P. J.

Utilizing Raman Spectroscopy as a Tool for Solid- and Solution-Phase Analysis of Metalloorganic Cage Host–Guest Complexes

Inorg. Chem. 2022,

DOI: 10.1021/acs.inorgchem.2c00873
TOC

Piskorz, T. K.; Martí-Centelles, V.; Young, T. A.; Lusby, P. J.; Duarte, F.

Computational Modeling of Supramolecular Metallo-Organic Cages–Challenges and Opportunities.

ACS. Catal. 2022, 12, 10, 5806-5826

DOI: 10.1021/acscatal.2c00837
TOC

Scott, A. J.; Vallejo, J.; Sarkar, A.; Smythe, L.; Martí, E. R.; Nichol, G. S.; Klooster, W. T.; Coles, S. J.; Murrie, M.; Rajaraman, G.; Piligkos, S.; Lusby, P. J.; Brechin, E. K.

Exploiting host–guest chemistry to manipulate magnetic interactions in metallosupramolecular M4L6 tetrahedral cages

Chem. Sci., 2021, 12, 5134-5142

DOI: 10.1039/D1SC00647A

O’Connor, H. M.; Sanz, S.; Scott, A. J.; Pitak, M. B.; Klooster, W. T.; Coles, S. J.; Chilton, N. F.; McInnes, E. J. L.; Lusby, P. J.; Weihe, H.; Piligkos, S.; Brechin, E. K.

[CrIII8NiII6]n+ Heterometallic Coordination Cubes

Molecules, 2021, 26(3), 757;

DOI: 10.3390/molecules26030757

Wang, J.; Young, T. A.; Duarte-González, F.; Lusby, P. J.

Synergistic Noncovalent Catalysis Facilitates Base-Free Michael Addition

J. Am. Chem. Soc., 2020, 142, 41, 17743–17750

DOI: 10.1021/jacs.0c08639

O’Connor, H. M.; Coletta, M.; Etcheverry-Berriós, A.; Nichol, G. S.; Brechin, E. K.; Lusby, P. J.

Kinetic selection of Pd4L2 metallocyclic and Pd6L3 trigonal prismatic assemblies

Chem. Commun., 2020, 56, 11799-11802

DOI: 10.1039/D0CC05311B

Martí-Centelles, V.; Spicer, R. L.; Lusby P. J.

Non-covalent allosteric regulation of capsule catalysis

Chem. Sci., 2020, 11, 3236-3240

DOI: 10.1039/D0SC00341G 

Spicer, R. L.; Stergiou, A. D.; Young, T. A.; Duarte, F.; Symes, M.; Lusby P. J.

Host–Guest-Induced Electron Transfer Triggers Radical-Cation Catalysis

J. Am. Chem. Soc. 2020, 142, 5, 2134-2139

DOI: 10.1021/jacs.9b11273

Young, T. A.; Martí-Centelles, V.; Wang, J.; Duarte, F.; Lusby P. J.

Rationalizing the Activity of an “Artificial Diels-Alderase”: Establishing Efficient and Accurate Protocols for Calculating Supramolecular Catalysis

J. Am. Chem. Soc. 2020, 142, 3, 1300-1310

DOI: 10.1021/jacs.9b10302

Borsley, S.; Haugland, M. M.; Oldknow, S.; Cooper, J. A.; Burke, M. J.; Scott, A.; Grantham, W. R.; Vallejo, J.; Brechin, E. K.; Lusby, P. J.; Cockroft, S. L.

Electrostatic Forces in Field-Perturbed Equilibria: Nanopore Analysis of Cage Complexes

Chem 2019, 5, 5, 1017-1019

DOI: 10.1016/j.chempr.2019.03.004

Martí-Centelles, V.; Duarte, F.; Lusby P. J.

Host‐Guest Chemistry of Self‐Assembled Hemi‐Cage Systems: The Dramatic Effect of Lost Pre‐Organization

Isr. J. Chem. 2019, 59, 3-4, 257-266

DOI: 10.1002/ijch.201800106

Tateishi, T.; Takahashi, S.; Okazawa, A.; Martí-Centelles, V.; Wang, J.; Kojima, T.; Lusby, P. J.; Sato, H.; Hiraoka, S.

Navigated Self-Assembly of a Pd2L4 Cage by Modulation of an Energy Landscape under Kinetic Control

J. Am. Chem. Soc. 2019, 141, 50, 19669-19676

DOI: 10.1021/jacs.9b07779

Burke B. P.; Grantham W. R.; Burke M. J.; Nichol G. S.; Roberts D.; Renard I.; Hargreaves R.; Cawthorne C.; Archibald S. J.; Lusby P. J.

Visualizing Kinetically Robust CoIII4L6 Assemblies in Vivo: SPECT Imaging of the Encapsulated [99mTc]TcO4– Anion

J. Am. Chem. Soc. 2018, 140, 49, 16877-16881

DOI: 10.1021/jacs.8b09582

Sanz, S.; O’Connor, H. M.; Comar, P.; Baldansuren, A.; Pitak, M. B.; Coles, S. J.; Weihe, H.; Chilton, N. F.; McInnes, E. J. L.; Lusby P. J.; Piligkos, S.; Brechin, E. K.

Modular [FeIII8MII6]n+ (MII = Pd, Co, Ni, Cu) Coordination Cages

Inorg. Chem. 2018, 57 (7), 3500–3506

DOI: 10.1021/acs.inorgchem.7b02674
TOC

Martí-Centelles, V.; Lawrence, A. L.; Lusby, P. J.

High Activity and Efficient Turnover by a Simple, Self-Assembled "Artificial Diels-Alderase"

J. Am. Chem. Soc. 2018, 140, 2862-2868.

DOI: 10.1021/jacs.7b12146
toc

Borsley, S.; Cooper, J. A.; Lusby, P. J.; Cockroft, S. L.

Nanopore Detection of Single-Molecule Binding within a Metallosupramolecular Cage

Chem. Eur. J. 2018, 24, 4542-4546.

DOI: 10.1002/chem.201800760
toc

Kai, S.; Martí-Centelles, V.; Sakuma, Y.; Mashito, T.; Kojima, T.; Nagashima, U.; Tachikawa, M.; Lusby, P. J.; Hiraoka, S.

Quantitative Analysis of Self-Assembly Process of a Pd2L4 Cage Consisting of Rigid Ditopic Ligands

Chem. Eur. J. 2017, 24, 663-671.

DOI: 10.1002/chem.201704285

Sanz, S.; O’Connor, H. M.; Martí-Centelles, V.; Comar, P.; Pitak, M. B.; Coles, S. J.; Lorusso, G.; Palacios, E.; Evangelisti, M.; Baldansuren, A.; Chilton, N. F.; Weihe, H.; McInnes, E. J. L.; Lusby, P. J.; Piligkos, S.; Brechin, E. K.

[MIII2MII3]n+ trigonal bipyramidal cages based on diamagnetic and paramagnetic metalloligands

Chem. Sci., 2017, 8, 5526-5535

DOI: 10.1039/C7SC00487G

Cooper, J. A.; Borsley, S.; Lusby, P. J.; Cockroft, S. L.

Discrimination of supramolecular chirality using a protein nanopore

Chem. Sci. 2017, 8, 5005-5009.

DOI: 10.1039/c7sc01940h

August, D. P.; Nichol, G. S.; Lusby, P. J.

Maximizing Coordination Capsule–Guest Polar Interactions in Apolar Solvents Reveals Significant Binding

Angew. Chem. Int. Ed. 2016, 55, ASAP.

DOI: 10.1002/anie.201608229

Burke, M. J.; Nichol, G. S.; Lusby, P. J.

Orthogonal Selection and Fixing of Coordination Self-Assembly Pathways for Robust Metallo-organic Ensemble Construction

J. Am. Chem. Soc. 2016, 138, 9308–9315.

DOI: 10.1021/jacs.6b05364

O'Connor, H. M.; Sanz, S.; Pitak, M. B.; Coles, S. J.; Nichol, G. S.; Piligkos, S.; Lusby, P. J.; Brechin, E. K.

[CrIII8MII6]n+ (MII = Cu, Co) face-centred, metallosupramolecular cubes

CrystEngComm 2016, 18, 4914–4920.

DOI: 10.1039/C6CE00654J

Sanz, S.; O'Connor, H. M.; Pineda, E. M.; Pedersen, K. S.; Nichol, G. S.; Mønsted, O.; Weihe, H.; Piligkos, S.; McInnes, E. J. L.; Lusby, P. J.; Brechin, E. K.

[Cr(III)8 M(II)6 ](12+) Coordination Cubes (M(II) =Cu, Co)

Angew. Chem. Int. Ed. 2015, 54, 6761–6764.

DOI: 10.1002/anie.201501041

Symmers, P. R.; Burke, M. J.; August, D. P.; Thomson, P. I. T.; Nichol, G. S.; Warren, M. R.; Campbell, C. J.; Lusby, P. J.

Non-equilibrium cobalt(III) "click" capsules

Chem. Sci. 2015, 6, 756–760.

DOI: 10.1039/C4SC03036B

Frost, J. M.; Sanz, S.; Rajeshkumar, T.; Pitak, M. B.; Coles, S. J.; Rajaraman, G.; Wernsdorfer, W.; Schnack, J.; Lusby, P. J.; Brechin, E. K.

A truncated [Mn(III)12] tetrahedron from oxime-based [Mn(III)3O] building blocks

Dalton Trans. 2014, 43, 10690–10694.

DOI: 10.1039/C4DT01469C

Sanz, S.; Frost, J. M.; Rajeshkumar, T.; Dalgarno, S. J.; Rajaraman, G.; Wernsdorfer, W.; Schnack, J.; Lusby, P. J.; Brechin, E. K.

Combining Complementary Ligands into one Framework for the Construction of a Ferromagnetically Coupled [Mn(III)12] Wheel

Chem. Eur. J. 2014, 20, 3010–3013.

DOI: 10.1002/chem.201304740

Sanz, S.; Frost, J. M.; Pitak, M. B.; Coles, S. J.; Piligkos, S.; Lusby, P. J.; Brechin, E. K.

"Converting" an hexametallic Mn(III) wheel to a dodecametallic Mn(III) wheel via ligand oximation

Chem. Commun. 2014, 50, 3310–3312.

DOI: 10.1039/C3CC49583C

Sooksawat, D.; Pike, S. J.; Slawin, A. M. Z.; Lusby, P. J.

Acid-base responsive switching between "3+1" and "2+2" platinum complexes

Chem. Commun. 2013, 49, 11077–11079.

DOI: 10.1039/C3CC46587J

Chepelin, O.; Ujma, J.; Wu, X.; Slawin, A. M. Z.; Pitak, M. B.; Coles, S. J.; Michel, J.; Jones, A. C.; Barran, P. E.; Lusby, P. J.

Luminescent, Enantiopure, Phenylatopyridine Iridium-Based Coordination Capsules

J. Am. Chem. Soc. 2012, 134, 19334–19337.

DOI: 10.1021/ja309031h

Chepelin, O.; Ujma, J.; Barran, P. E.; Lusby, P. J.

Sequential, Kinetically Controlled Synthesis of Multicomponent Stereoisomeric Assemblies

Angew. Chem. Int. Ed. 2012, 51, 4194–4197.

DOI: 10.1002/anie.201108994

Inside Cover

Inside cover of Angewandte Chemie

Ujma, J.; De Cecco, M.; Chepelin, O.; Levene, H.; Moffat, C.; Pike, S. J.; Lusby, P. J.; Barran, P. E.

Shapes of supramolecular cages by ion mobility mass spectrometry

Chem. Commun. 2012, 48, 4423–4425.

DOI: 10.1039/C2CC30778B

Pike, S. J.; Lusby, P. J.

Dual stimuli-responsive interconvertible heteroleptic platinum coordination modes

Chem. Commun. 2010, 46, 8338–8340.

DOI: 10.1039/C0CC01668C

Inside Cover

Inside cover of ChemComm

Leigh, D. A., Lusby, P. J., McBurney, R. T., Symes, M. D.

Improved dynamics and positional bias with a second generation palladium(II)-complexed molecular shuttle

Chem. Commun. 2010, 46, 2382–2384.

DOI: 10.1039/C001697G

Lusby, P. J., Mueller, P., Pike, S. J., Slawin, A. M. Z

Stimuli-Responsive Reversible Assembly of 2D and 3D Metallosupramolecular Architectures

J. Am. Chem. Soc. 2009, 131, 16398–16400.

DOI: 10.1021/ja907297z

Goldup, S. M., Leigh, D. A., Lusby, P. J., McBurney, R. T., Slawin, A. M. Z.

Active template synthesis of rotaxanes and molecular shuttles with switchable dynamics by four-component Pd-II-promoted Michael additions

Angew. Chem. Int. 2008, 47, 3381–3384.

DOI: 10.1002/anie.200705859

Barrell, M. J., Leigh, D. A., Lusby, P. J., Slawin, A. M. Z.

An Ion-Pair Template for Rotaxane Formation and its Exploitation in an Orthogonal Interaction Anion-Switchahle Molecular Shuttle

Angew. Chem. Int. 2008, 47, 8036–8039.

DOI: 10.1002/anie.200802745